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Oral arginine metabolism may decrease the risk for dental caries in children.

M M Nascimento1, Y Liu, R Kalra

  • 1Department of Restorative Dental Sciences, Division of Operative Dentistry, University of Florida, Gainesville, FL, USA. mnascimento@dental.ufl.edu

Journal of Dental Research
|May 4, 2013
PubMed
Summary
This summary is machine-generated.

Oral bacteria arginine metabolism via the arginine deiminase system (ADS) increases pH, potentially preventing cavities. Higher ADS activity was found in healthy plaque compared to decayed sites, suggesting a protective role against dental caries in children.

Keywords:
argininebacteriadental cariesdental plaqueoral biolfimrisk factor

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Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
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Published on: December 16, 2021

Area of Science:

  • Microbiology
  • Biochemistry
  • Dental Research

Background:

  • Arginine metabolism by oral bacteria, specifically the arginine deiminase system (ADS), elevates local pH.
  • This pH increase can counteract acid production from sugar metabolism, reducing oral biofilm cariogenicity.
  • Understanding the link between arginine metabolism and dental caries in children is crucial for preventive strategies.

Purpose of the Study:

  • To investigate the relationship between oral arginine metabolism and dental caries experience in children.
  • To measure arginine deiminase system (ADS) activity in oral samples from children.
  • To correlate ADS activity with caries status and dentition type.

Main Methods:

  • Collected supragingival dental plaque from caries-lesion-free (PF), dentinal (PD), and enamel (PE) caries lesions in 100 children.
  • Measured ADS activity in plaque samples.
  • Analyzed salivary arginolytic activity.
  • Utilized mixed-model analysis to assess associations between plaque ADS activity and caries status, controlling for age and dentition.

Main Results:

  • Significantly higher ADS activity was observed in caries-lesion-free plaque (PF) compared to plaque from dentinal (PD) and enamel (PE) caries lesions.
  • No significant difference in salivary arginolytic activity was found across different caries statuses.
  • Plaque caries status was significantly associated with ADS activity, with healthy plaque exhibiting higher ADS activity than diseased plaque.

Conclusions:

  • Plaque arginine metabolism, specifically ADS activity, is significantly associated with dental caries status in children.
  • Higher ADS activity in healthy plaque suggests a potential protective role against caries development.
  • Variations in plaque arginine metabolism among children and tooth sites may influence caries susceptibility.