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Related Concept Videos

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
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Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Pharmaceutical Equivalents01:26

Pharmaceutical Equivalents

As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...

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Anti-counterfeit technologies: a pharmaceutical industry perspective.

Dipika Bansal1, Swathi Malla, Kapil Gudala

  • 1Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S Nagar, Punjab-160062, India.

Scientia Pharmaceutica
|May 4, 2013
PubMed
Summary

Technological solutions are crucial for combating the global rise of counterfeit drugs. This review examines anti-counterfeit technologies and their international adoption to protect pharmaceutical supply chains.

Keywords:
Anti-counterfeit technologyAuthenticationPedigreeRFIDSerialization

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Area of Science:

  • Pharmaceutical Science
  • Technology & Innovation

Background:

  • International free trade and insufficient drug regulation fuel the global counterfeit drug market.
  • Counterfeit medicines pose a significant threat to public health and safety worldwide.

Purpose of the Study:

  • To review ideal technological characteristics for anti-counterfeit measures.
  • To examine existing technologies and their adoption rates in different countries.
  • To highlight the role of technology in preventing counterfeit drugs within pharmaceutical supply chains.

Main Methods:

  • Literature review of technological protection strategies against counterfeit drugs.
  • Analysis of overt, covert, and track and trace technologies.
  • Comparative assessment of technology adoption in developed and developing countries.

Main Results:

  • Radio Frequency Identification (RFID) is adopted in the USA; 2D barcodes are trending in Europe.
  • The Indian government is mandating barcodes to combat counterfeit drugs.
  • Pharmaceutical companies are increasingly implementing technologies to secure their supply chains.

Conclusions:

  • Technological interventions are essential for mitigating the risks associated with counterfeit pharmaceuticals.
  • A multi-faceted approach involving government regulation and industry adoption of technologies is key.
  • Continued innovation and implementation of track and trace systems are vital for global drug safety.