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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Histology of the Small Intestine01:27

Histology of the Small Intestine

The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...

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Related Experiment Video

Updated: May 11, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
07:05

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

[Microscopic colitis].

Karel Lukáš1, Václav Mandys

  • 1Interni Klinika 1. LF UK a VFN, Praha. klukas@vfn.cz

Casopis Lekaru Ceskych
|May 7, 2013
PubMed
Summary
This summary is machine-generated.

Microscopic colitis causes chronic watery diarrhea, often in older adults. Diagnosis involves clinical review and biopsies, with treatments focusing on symptom relief or anti-inflammatory drugs.

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Last Updated: May 11, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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Published on: December 15, 2017

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
09:42

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

Published on: August 26, 2014

Area of Science:

  • Gastroenterology
  • Internal Medicine

Background:

  • Microscopic colitis is a significant cause of chronic watery diarrhea, particularly in older individuals.
  • The exact pathogenic mechanisms underlying microscopic colitis are not fully understood.
  • It encompasses various subtypes, including collagenous colitis, lymphocytic colitis, and others.

Purpose of the Study:

  • To review the clinical presentation, diagnostic methods, and treatment options for microscopic colitis.
  • To highlight the importance of colonic mucosal biopsies in diagnosis.
  • To summarize current therapeutic strategies for managing microscopic colitis.

Main Methods:

  • Review of clinical features associated with microscopic colitis.
  • Emphasis on histopathological examination of colonic mucosal biopsies for diagnosis.
  • Analysis of proposed treatment modalities based on case reports and clinical experience.

Main Results:

  • Microscopic colitis is characterized by chronic or intermittent watery diarrhea.
  • Diagnosis relies on correlating clinical symptoms with findings from colonic biopsies.
  • Treatment approaches include symptomatic relief and anti-inflammatory or immunosuppressive agents.

Conclusions:

  • Accurate diagnosis of microscopic colitis requires careful clinical assessment and biopsy review.
  • Treatment strategies vary, aiming for symptomatic control or modulation of underlying inflammation.
  • Further research into pathogenesis may lead to more targeted therapies.