Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A novel serum-free medium for the isolation, expansion and maintenance of stemness and tissue-specific markers of primary human periodontal ligament cells.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2020

Same author

Modeling psychiatric disorders: from genomic findings to cellular phenotypes.

Molecular psychiatry·2016

Same author

Modeling psychiatric disorders: from genomic findings to cellular phenotypes.

Molecular psychiatry·2016

Same author

Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI).

Regenerative medicine·2015

Same author

Pluripotent stem cell-derived somatic stem cells as tool to study the role of microRNAs in early human neural development.

Current molecular medicine·2013

Same author

[Human embryonic stem cells. Perspectives for the study and therapy of neurological disorders].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2008

Search research articles

Related Experiment Video

Updated: May 11, 2026

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

Published on: June 10, 2021

Disease-specific iPS cell models in neuroscience.

M Peitz¹, J Jungverdorben, O Brüstle

¹Institute of Reconstructive Neurobiology, University of Bonn LIFE & BRAIN Center, and LIFE & BRAIN GmbH, Sigmund-Freud Strasse 25, D- 53127 Bonn, Germany. brustle@uni-bonn.de

Current Molecular Medicine

|May 7, 2013

Summary

This summary is machine-generated.

Human induced pluripotent stem (hiPS) cells offer a powerful in vitro model for studying neurodegenerative diseases. These patient-specific cells overcome limitations of traditional models, aiding research into disease mechanisms.

More Related Videos

Precise Brain Mapping to Perform Repetitive In Vivo Imaging of Neuro-Immune Dynamics in Mice

Precise Brain Mapping to Perform Repetitive In Vivo Imaging of Neuro-Immune Dynamics in Mice

Published on: August 7, 2020

Related Experiment Videos

Last Updated: May 11, 2026

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

Published on: June 10, 2021

Precise Brain Mapping to Perform Repetitive In Vivo Imaging of Neuro-Immune Dynamics in Mice

Precise Brain Mapping to Perform Repetitive In Vivo Imaging of Neuro-Immune Dynamics in Mice

Published on: August 7, 2020

Area of Science:

Neuroscience
Stem Cell Biology
Genetics

Background:

Neurodegenerative diseases involve progressive neural cell loss, posing research challenges due to limited human tissue access.
Existing models like cell lines and animal models often lack physiological relevance and human context.
Disease initiation precedes symptoms, making late-stage tissue analysis insufficient for understanding early molecular events.

Purpose of the Study:

To review the progress and applications of human induced pluripotent stem (hiPS) cell-based models in neurodegenerative disease research.
To highlight the advantages of hiPS cells over traditional experimental systems.
To discuss advancements in assessing the quality of hiPS cell lines for reliable disease modeling.

Main Methods:

Utilizing patient-derived somatic cells to generate human induced pluripotent stem (hiPS) cells.
Employing hiPS cells for in vitro modeling of neurological disorders.
Reviewing current literature on hiPS cell applications and quality assessment techniques.

Main Results:

hiPS cells provide patient-specific, virtually unlimited cellular resources for in vitro disease modeling.
These models offer a more physiologically relevant context compared to cell lines or animal models.
Advances in quality assessment are crucial for ensuring the reliability of hiPS cell-based studies.

Conclusions:

hiPS cell technology represents a significant advancement in modeling neurodegenerative diseases.
This approach facilitates the study of molecular pathomechanisms in a humanized context.
Further development in hiPS cell quality control will enhance their utility in translational research.