Physiological differentiation within the auditory part of the thalamic reticular nucleus of the cat

Spike trains of 153 single units were recorded in the caudoventral part of the thalamic reticular nucleus (RE) of 7 nitrous oxide anaesthetized cats. Functional properties defined by spontaneous activity pattern, studied by mean of auto renewal density histograms, were used to subdivide the units into 4 groups. Types I (18%), II (56%) and III (15%) were defined by an increasing bursting activity and Type IV (11%) by firing no bursts spontaneously. The responses to auditory stimuli confirmed that the caudoventral part of RE is tightly related to central auditory pathways. Responses to white noise bursts (200 ms duration) significantly let appear that Type I units responded in a high proportion (greater than 70%) until 80 ms after the stimulus onset, Type II units where mostly affected during the entire stimulus duration, and Type III units showed preferentially late responses. The units responsive to high frequencies (greater than 8 kHz) were mostly located in the dorsal and the units responsive to low frequencies (less than 2 kHz) in the anteroventral sector of auditory RE. However, only a loosely tonotopy is supported by this study. The neuronal circuitry within RE was shown to be stable when white noise bursts were delivered. Cross-correlograms indicated a large proportion of interconnected units (64%) and signs of mutual inhibition between neighboring RE units (11%). The hypothesis is discussed that the auditory RE exerts a fine control on the time-dependent analysis of the incoming auditory input to the cerebral cortex. The complex intranuclear connectivity suggests that the cell types correspond to distinct patterns of functional connections.