Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Stereoisomerism02:52

Stereoisomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New chemotherapeutic strategies against mesenchymal triple-negative breast cancer: A deeper look at the molecular level.

Talanta·2026
Same author

Corrigendum to "Co-occurrence of microplastics and endocrine-disrupting chemicals in subantarctic seabirds" [J. Hazd. Mater. 509 (2026) 142018].

Journal of hazardous materials·2026
Same author

Activation, Steady-State and Passivation Regimes for Ethene Hydrogenation over a Pd/Al <b><sub>2</sub></b> O <b><sub>3</sub></b> Catalyst: An <i>Operando</i> Neutron Imaging Study.

The journal of physical chemistry. C, Nanomaterials and interfaces·2026
Same author

Triple-Negative Breast Cancer Versus Non-Triple-Negative Breast Cancer: The Impact of Pd and Pt Complexes on Basal-Like Triple-Negative Breast Cancer.

ChemMedChem·2026
Same author

Inelastic neutron scattering of catalysts and computational studies: a synergistic pairing.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026
Same author

Liquefaction of <i>Ruscus aculeatus</i> Branches into Bio-Polyols: Process Optimization and Polyol Characterization.

Polymers·2026

Related Experiment Video

Updated: May 11, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Polymorphism in cisplatin anticancer drug.

M Paula M Marques1, Rosendo Valero, Stewart F Parker

  • 1Research Unit Molecular Physical Chemistry, Faculty of Science and Technology, University of Coimbra, 3004-535 Coimbra, Portugal. pmc@ci.uc.pt

The Journal of Physical Chemistry. B
|May 7, 2013
PubMed
Summary

This study investigates cisplatin

Area of Science:

  • Solid-state chemistry
  • Materials science
  • Pharmaceutical sciences

Background:

  • Cisplatin is a widely used anticancer drug.
  • Understanding its solid-state polymorphism is crucial for drug formulation.
  • Polymorphic transitions can affect drug stability and efficacy.

Purpose of the Study:

  • To investigate the solid-state polymorphism of cisplatin.
  • To determine the relative thermal stability of cisplatin's α and β polymorphs.
  • To elucidate the polymorphic equilibrium for optimized pharmaceutical applications.

Main Methods:

  • Combined experimental and theoretical approach.
  • Simultaneous inelastic neutron scattering (INS) and Raman spectroscopy at variable temperatures.
  • Density functional theory (DFT) calculations with plane-wave basis sets and pseudopotentials.

More Related Videos

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

Related Experiment Videos

Last Updated: May 11, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

Main Results:

  • Observed temperature-dependent hysteresis in polymorphic transitions.
  • Identified α polymorph at low temperatures and β polymorph near room temperature.
  • Determined regions of coexistence for both polymorphs, dependent on heating/cooling cycles.

Conclusions:

  • Raman spectroscopy can clearly identify and discriminate between cisplatin polymorphs.
  • Elucidating polymorphic equilibrium is vital for cisplatin's pharmaceutical preparation and storage.
  • Findings contribute to the stable formulation of this important anticancer agent.