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Coagulation

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...

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Related Experiment Video

Updated: May 11, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Microfluidics and coagulation biology.

Thomas V Colace¹, Garth W Tormoen, Owen J T McCarty

¹Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

Annual Review of Biomedical Engineering

|May 7, 2013

Summary

This summary is machine-generated.

Microfluidic devices enable detailed study of blood clotting (thrombosis) ex vivo. These advanced tools aid in understanding platelet function and developing new clinical diagnostics and drug testing methods.

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Last Updated: May 11, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Published on: February 14, 2017

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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Area of Science:

Biomedical Engineering
Hematology
Microfluidics

Background:

Blood studies ex vivo utilize open or closed systems, with or without flow.
Microfluidic devices offer precise control over fluid dynamics at the submillimeter scale.
These devices are crucial for analyzing complex biological processes like platelet function and coagulation.

Purpose of the Study:

To highlight the utility of microfluidic devices in studying blood ex vivo.
To demonstrate the application of microfluidics in analyzing thrombotic events.
To explore the potential of microfluidics in clinical diagnostics and drug testing.

Main Methods:

Utilizing microfluidic devices to study platelet function, coagulation, biorheology, and adhesion dynamics.
Investigating thrombotic events on defined surfaces under controlled flow or pressure conditions.
Employing multicolor imaging for platelets, fibrin, and phosphatidylserine within microfluidic systems.

Main Results:

Microfluidics allows for the study of thousands of thrombotic events in a single session.
Enabled determination of intraluminal thrombus permeability.
Discovered that sudden flow decrease can activate platelet contractility.
Provided a human blood analog for studying injury models.

Conclusions:

Microfluidic devices are invaluable tools for ex vivo blood analysis.
They offer significant opportunities for research, drug testing under hemodynamic conditions, and clinical diagnostics.
Advances in microfluidics enhance our understanding of hemostasis and thrombosis.