Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons.

Cell·2025
Same author

Development of GABAergic Interneurons in the Human Cerebral Cortex.

The European journal of neuroscience·2025
Same author

Regulation of PV interneuron plasticity by neuropeptide-encoding genes.

Nature·2025
Same author

Somatostatin interneurons control the timing of developmental desynchronization in cortical networks.

Neuron·2024
Same author

Parvalbumin interneuron deficits in schizophrenia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2024
Same author

Cortical somatostatin long-range projection neurons and interneurons exhibit divergent developmental trajectories.

Neuron·2023
Same journal

Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis.

Cell stem cell·2026
Same journal

Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis.

Cell stem cell·2026
Same journal

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation.

Cell stem cell·2026
Same journal

Paired pre- and post-transplant human immunoprofiling identifies an IFN-γ-JAK1 axis limiting stem-cell-derived RPE engraftment.

Cell stem cell·2026
Same journal

ENPP1 blockade with a humanized monoclonal antibody enhances renal repair after acute kidney injury.

Cell stem cell·2026
Same journal

ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation.

Cell stem cell·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Human cortical interneurons take their time.

Oscar Marín1

  • 1Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain. o.marin@umh.es

Cell Stem Cell
|May 7, 2013
PubMed
Summary
This summary is machine-generated.

Researchers developed methods to derive cortical interneurons from human pluripotent stem cells. These cells mature slowly, mimicking human development, and show promise for modeling brain development and diseases.

More Related Videos

Multi-electrode Array Recordings of Neuronal Avalanches in Organotypic Cultures
16:01

Multi-electrode Array Recordings of Neuronal Avalanches in Organotypic Cultures

Published on: August 1, 2011

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors
10:24

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

Related Experiment Videos

Last Updated: May 11, 2026

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Multi-electrode Array Recordings of Neuronal Avalanches in Organotypic Cultures
16:01

Multi-electrode Array Recordings of Neuronal Avalanches in Organotypic Cultures

Published on: August 1, 2011

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors
10:24

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Research

Background:

  • Deriving specific neuronal subtypes from human pluripotent stem cells (hPSCs) is crucial for understanding human brain development and neurological disorders.
  • Cortical interneurons play vital roles in regulating neural circuit activity and are implicated in various neurodevelopmental and psychiatric conditions.

Discussion:

  • Maroof et al. and Nicholas et al. present novel strategies for generating cortical interneurons from hPSCs.
  • The derived interneurons exhibit a prolonged functional maturation period, mirroring the timeline of in vivo human cortical development.
  • This extended maturation suggests the potential for these cells to serve as a valuable tool for studying developmental processes.

Key Insights:

  • Successful derivation of functional cortical interneurons from hPSCs has been achieved.
  • The observed protracted maturation phase is a key characteristic relevant to human neurodevelopment.
  • These findings provide a foundation for using hPSC-derived interneurons in disease modeling.

Outlook:

  • hPSC-derived cortical interneurons offer a promising avenue for in vitro modeling of human brain development and diseases.
  • Further research can explore the application of these cellular models for drug screening and therapeutic target identification.
  • Investigating the precise mechanisms underlying the functional maturation of these neurons could yield new insights into neuronal development.