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Extensively hydrolyzed protein formula reduces acid gastro-esophageal reflux in symptomatic preterm infants

Luigi Corvaglia1, Elisa Mariani, Arianna Aceti

  • 1Neonatology and Neonatal Intensive Care Unit, S. Orsola-Malpighi Hospital, University of Bologna, Italy. luigi.corvaglia@unibo.it

Early Human Development
|May 7, 2013
PubMed

Insights

An extensively hydrolyzed protein formula (eHPF) effectively reduced gastro-esophageal reflux (GER) events and reflux index in preterm infants experiencing feeding intolerance. This dietary change offers a promising alternative for managing GER symptoms in this vulnerable population.

Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Infant Nutrition

Background:

  • Gastro-esophageal reflux (GER) is common in preterm infants, often managed with conservative measures.
  • Pharmacological treatments for GER carry potential side effects, highlighting the need for safer alternatives.
  • Feeding intolerance is a frequent issue in formula-fed preterm infants, with hydrolyzed protein formulas (HPF) used to improve gastrointestinal motility.

Purpose of the Study:

  • To evaluate the impact of an extensively hydrolyzed protein formula (eHPF) on GER indices.
  • To assess the efficacy of eHPF in formula-fed preterm infants presenting with both GER and feeding intolerance symptoms.

Main Methods:

  • A randomized crossover trial was conducted involving preterm infants (gestational age ≤33 weeks).
  • Infants experienced symptoms of both feeding intolerance and GER.
  • GER indices were measured using 24-h combined multichannel intraluminal impedance and pH monitoring after feeding with eHPF and standard preterm formula (SPF).

Main Results:

  • The extensively hydrolyzed protein formula (eHPF) significantly decreased the number of GER events detected by pH monitoring compared to SPF.
  • eHPF also led to a significant reduction in the reflux index.
  • No significant differences were observed in impedance bolus exposure indices or GER height between the two formulas.

Conclusions:

  • The use of eHPF shows potential for reducing esophageal acid exposure in preterm infants with feeding intolerance and GER symptoms.
  • Further research is warranted to evaluate specific eHPFs for preterm infants to improve clinical GER symptoms.
Abstract

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