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Immunochemotherapy (thymostimulin/cyclophosphamide) in dogs

J A Montoya1, E M Martínez, M Rodríguez

  • 1Dpto. de Patología Animal, Facultad de Veterinaria, Madrid, Spain.

The British Veterinary Journal
|May 1, 1990
PubMed

This article demonstrates the positive effect of thymostimulin (TP-1) on leucolymphopoiesis in dogs, based on its apparent ability to counteract the immunodepression induced by cyclophosphamide chemotherapy. Thymostimulin administered to healthy cyclophosphamide-treated dogs prevented the initial drop in the values of leucocytes and lymphocytes due to the chemotherapy and restored these values to the higher levels existing before the treatment. In a control group given a placebo instead of TP-1, the immune depression provoked by cyclophosphamide was maintained during all the therapeutic cycles.

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