Related Experiment Videos
Amphetamine lowers extracellular GABA concentration in the ventral pallidum
1Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520.
Brain Research
|May 14, 1990
Abstract:
In vivo dialysis was performed in the ventral pallidum of the conscious rat, and extracellular levels of gamma-aminobutyric acid (GABA) measured. Forty minutes following peripheral administration of amphetamine (2.0 mg/kg, s.c.) the extracellular concentration of GABA was significantly reduced, in parallel with a significant elevation in motor activity. These data indicate that a decline in GABA transmission in the ventral pallidum may be important in the initiation of amphetamine-induced motor activity.