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Short-term decrease of skin-test sensitivity after rush desensitization in Hymenoptera venom hypersensitivity.

A Tsicopoulos1, A B Tonnel, B Wallaert

  • 1INSERM U167-CNRS 624, Institut Pasteur, Lille, France.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|May 1, 1990
PubMed
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Rush immunotherapy effectively reduced skin test sensitivity in patients with systemic anaphylactic sting reactions. This desensitization correlated with decreased platelet reactivity, not significant changes in IgE or IgG antibody levels.

Area of Science:

  • Allergy and Immunology
  • Clinical Medicine
  • Toxicology

Background:

  • Systemic anaphylactic stings pose significant health risks.
  • Rush immunotherapy is a rapid desensitization method for allergic reactions.
  • Hymenoptera venom allergies require effective management strategies.

Purpose of the Study:

  • To evaluate the efficacy of rush immunotherapy in reducing skin test sensitivity in patients with systemic anaphylactic sting reactions.
  • To investigate the correlation between skin test sensitivity changes and specific IgE/IgG antibody levels and platelet reactivity.
  • To assess the reproducibility of skin testing techniques over time.

Main Methods:

  • Thirty-seven patients with a history of systemic anaphylactic stings underwent rush immunotherapy.

Related Experiment Videos

  • Skin testing was performed before and 6 weeks after desensitization.
  • A control group of 10 patients was tested for reproducibility.
  • Results were compared with specific IgE, IgG antibody levels, and platelet reactivity to Hymenoptera venom.

    • Main Results:

    • Skin test sensitivity decreased significantly after rush immunotherapy (P < 0.001).
    • 75% of patients showed reduced skin test sensitivity.
    • Decreased skin test sensitivity correlated with reduced platelet reactivity (P < 0.05).
    • No significant changes in specific IgE or IgG antibody levels were observed.
    • Skin test sensitivity in the control group remained stable.

    Conclusions:

    • Rush immunotherapy is effective in reducing skin test sensitivity in patients with Hymenoptera venom allergy.
    • The desensitization process is linked to decreased platelet reactivity.
    • IgE and IgG antibody levels do not appear to be primary indicators of successful desensitization in this context.