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Updated: May 11, 2026
09:31
Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
Published on: September 17, 2021
[Oxidative stress in Crohn's disease]
Inés Moret1, Elena Cerrillo2, Ana Navarro-Puche3
1Instituto de Investigación Sanitaria, Hospital La Fe, Valencia, España; CIBEREHD, España.
Gastroenterologia Y Hepatologia
|May 7, 2013
Summary
Oxidative stress, an imbalance between reactive oxygen species (ROS) and antioxidants, is a key factor in Crohn's disease (CD) inflammation. This study reviews findings on oxidative stress in the gut and blood of CD patients.
Area of Science:
- Gastroenterology
- Immunology
- Biochemistry
Background:
- Crohn's disease (CD) involves transmural inflammation, often in the terminal ileum.
- Unregulated immune responses in CD lead to high reactive oxygen species (ROS) production.
- Antioxidant defenses normally regulate ROS, but an imbalance causes oxidative stress.
Purpose of the Study:
- To summarize key findings on oxidative stress in Crohn's disease.
- To investigate the role of oxidative stress in intestinal mucosa and peripheral blood.
Main Methods:
- Review of significant research findings.
- Analysis of oxidative stress markers in intestinal and blood samples.
Main Results:
- Oxidative stress is a significant feature in Crohn's disease.
- Imbalance between ROS production and antioxidant capacity is evident.
Conclusions:
- Oxidative stress plays a crucial role in the pathophysiology of Crohn's disease.
- Further research into oxidative stress mechanisms is warranted for therapeutic strategies.
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