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Related Experiment Videos

Lymphomas in dogs. A morphologic, immunologic, and clinical study.

P G Greenlee1, D A Filippa, F W Quimby

  • 1Department of Pathology, Cornell University Medical College, New York.

Cancer
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

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Canine lymphomas were classified using human schemes, with diffuse large cell and immunoblastic types being most common. High-grade tumors correlated with longer survival and remission, unlike T-cell tumors which had shorter outcomes.

Area of Science:

  • Veterinary Oncology
  • Immunology
  • Cancer Classification

Background:

  • Canine lymphoma classification has historically relied on morphology, but immunophenotyping offers deeper insights.
  • Human lymphoma classification schemes provide a framework for understanding canine counterparts.
  • Understanding canine lymphoma subtypes is crucial for predicting prognosis and treatment response.

Purpose of the Study:

  • To classify canine lymphomas using established human morphological schemes.
  • To determine the immunophenotype of canine lymphomas using cell surface markers.
  • To correlate morphological and immunophenotypic findings with clinical outcomes such as survival and remission.

Main Methods:

  • Morphological classification of 176 canine lymphomas using Rappaport, Lukes-Collins, Kiel, and Working Formulation schemes.

Related Experiment Videos

  • Immunophenotyping of 62 lymphomas via automated cytofluorography to analyze cell surface markers.
  • Statistical analysis to correlate classifications with survival, remission, and clinical parameters.

    • Main Results:

    • Diffuse large cell (centroblastic) and immunoblastic lymphomas were the most prevalent types.
    • The Kiel classification system proved most effective for canine lymphoma categorization.
    • Immunophenotyping revealed three main categories: pan-T(LQ1)+SIg+, pan-T(LQ1)-SIg+, and pan-T(LQ1)+SIg-.
    • High-grade lymphomas showed longer survival and remission periods.
    • T-cell lymphomas exhibited shorter remission and survival times compared to B-cell lymphomas.
    • A significant correlation was found between the pan-T(LQ1)+SIg- phenotype and hypercalcemia.

    Conclusions:

    • The Kiel classification is a valuable tool for canine lymphoma morphology.
    • Immunophenotyping provides critical prognostic information, differentiating T-cell and B-cell lymphomas.
    • High-grade canine lymphomas, despite their aggressive morphology, may have a better prognosis than previously thought.
    • Further research into the pan-T(LQ1)+SIg- phenotype and its association with hypercalcemia is warranted.