Related Experiment Video
Updated: May 11, 2026

An Ex vivo Model to Study Hormone Action in the Human Breast
Published on: January 8, 2015
Nutritional factors, physical activity, and breast cancer by hormonal receptor status
Valentina Rosato1, Paola Bertuccio, Cristina Bosetti
1Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Via Giuseppe La Masa 19, 20156 Milan, Italy; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Purpose:
To investigate the association between food and nutrient intake, occupational and leisure-time physical activity, and body mass index and breast cancer risk by estrogen receptor (ER) and progesterone receptor (PR) status.
Methods:
We analyzed data from a hospital-based case-control study conducted between 1991 and 1994 in Italy, including 1075 women with incident breast cancer and 1477 controls.
Results:
The associations with breast cancer risk were similar according to ER status for all risk factors considered. In particular, significant reduced risk of ER- and ER+ breast cancers were observed for raw vegetables (multivariate odds ratio, OR, for high vs low consumption: 0.6 and 0.7, respectively) and for polyunsaturated fats (OR: 0.6 and 0.7, respectively). No significant heterogeneous risk estimates were observed for combinations of ER and PR status.
Conclusions:
Our study does not suggest major differences risk for various dietary and lifestyle factors according to ER and PR breast cancer subtypes.
Related Concept Videos
Cancer Prevention
Some...
Cancer Prevention
Some...
Mitogens and the Cell Cycle
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Intracellular Hormone Receptors
Cancer Survival Analysis
