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GM-Free Generation of Blood-Derived Neuronal Cells

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Published on: February 13, 2021

Neuroglobin expression in neurogenesis.

Bryan Haines¹, Xiaoou Mao, Lin Xie

¹Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.

Neuroscience Letters

|May 7, 2013

Summary

This summary is machine-generated.

Neuroglobin (Ngb) protein is present in neural stem cells and increases during neuronal differentiation. This suggests Ngb may play a role in neurodevelopment.

Keywords:

Dcx GFAP NSC Neurogenesis Neuroglobin Ngb SVZ Stem cell Subventricular zone doublecortin glial fibrillary acidic protein hESC human embryonic stem cells neural stem cell neuroglobin subventricular zone

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Area of Science:

Neuroscience
Developmental Biology
Biochemistry

Background:

Neuroglobin (Ngb) is a hypoxia-inducible, neuroprotective protein.
Its role in neurodevelopment remains largely unknown.
Ngb is structurally related to myoglobin and hemoglobin.

Purpose of the Study:

To investigate the neurodevelopmental expression of neuroglobin.
To explore the function of neuroglobin during neuronal differentiation.

Main Methods:

Western blotting was used to measure neuroglobin protein levels.
Experiments were conducted on human embryonic stem cells differentiating into neurons in vitro.
Neuroglobin expression was analyzed in the neurogenic subventricular zone of adult rats in vivo.

Main Results:

Neuroglobin protein was barely detectable in human embryonic stem cells.
Neuroglobin expression was readily demonstrable in neural stem cells.
Neuroglobin levels increased upon differentiation into neurons.
In adult rats, neuroglobin expression in the subventricular zone correlated with the neuronal marker doublecortin.

Conclusions:

Neuroglobin is expressed early in neuronal differentiation.
Neuroglobin may have a significant role in neurodevelopment.
These findings provide insights into the developmental function of neuroglobin.