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[Congestive heart failure treated by a combination of cyclovirobuxine D with digoxin]
1Shanghai Jin-An District Central Hospital.
Insights
Combination therapy with digoxin and cyclovirobuxine D showed a 45.5% positive effect in congestive heart failure patients. Serum digoxin levels remained stable, supporting long-term, safe use of this combined treatment.
Area of Science:
- Cardiology
- Pharmacology
- Internal Medicine
Background:
- Congestive heart failure (CHF) remains a significant cause of morbidity and mortality.
- Optimizing pharmacotherapy for CHF is crucial for improving patient outcomes.
- Combination therapy may offer synergistic benefits in managing complex cardiac conditions.
Purpose of the Study:
- To evaluate the efficacy and safety of combined digoxin and cyclovirobuxine D in treating congestive heart failure.
- To assess the impact of this combination therapy on serum digoxin concentrations.
- To provide pharmacokinetic rationale for the long-term use of digoxin and cyclovirobuxine D.
Main Methods:
- A cohort of patients with congestive heart failure received combined treatment with digoxin and cyclovirobuxine D.
- Treatment outcomes were assessed, with a focus on the overall positive effect rate.
- Serum digoxin concentrations were measured before and after the combined treatment period in a subset of patients.
Main Results:
- The combination therapy demonstrated a promising positive effect in 45.5% of patients.
- Serum concentrations of digoxin showed no significant difference before and after the combined treatment (P < 0.05).
- These findings suggest predictable drug behavior within the combination.
Conclusions:
- Combined digoxin and cyclovirobuxine D therapy is effective in a notable percentage of congestive heart failure patients.
- The stability of serum digoxin levels supports the safety profile for extended treatment durations.
- This study provides a pharmacokinetic basis for the long-term and safe application of this dual-drug regimen.
Abstract:
The patients with congestive heart failure which were treated by combination of digoxin with cyclovirobuxine D were described, with good result, of which prominating effect was 45.5%. Researchful result of 11 patients showed serum concentration of digoxin before and after combined treatment was not obviously different (P less than 0.05). Basis of pharmacokinetics was provided for using combined treatment of these drugs with long time and greater safeness.