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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Published on: February 8, 2019

Giant cell arteritis: a multicenter observational study in Brazil.

Alexandre Wagner Silva de Souza1, Karine Yoshiye Kajiyama Okamoto, Fabiano Abrantes

  • 1Rheumatology Division, Universidade Federal de São Paulo, São Paulo, SP, Brazil. alexandre_wagner@uol.com.br

Clinics (Sao Paulo, Brazil)
|May 7, 2013
PubMed
Summary

Giant cell arteritis (GCA) in Brazil shows similar features to other regions, but with a higher rate of neuro-ophthalmic issues and blindness. Aspirin use was linked to fewer GCA relapses.

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Published on: June 5, 2010

Area of Science:

  • Rheumatology
  • Vasculitis Research
  • Clinical Epidemiology

Background:

  • Giant cell arteritis (GCA) is a systemic vasculitis primarily affecting older adults.
  • Understanding demographic and clinical variations in GCA is crucial for effective management.
  • Brazilian GCA patient data is less represented in global literature.

Purpose of the Study:

  • To delineate demographic characteristics, clinical presentations, and therapeutic approaches for GCA patients in Brazil.
  • To identify unique features of GCA in the Brazilian population compared to international cohorts.

Main Methods:

  • Retrospective cohort study involving 45 GCA patients from three Brazilian university hospitals.
  • Diagnosis adherence to American College of Rheumatology criteria or temporal artery biopsy.
  • Data collection on demographics, disease manifestations, treatments, and outcomes.

Main Results:

  • Caucasian ethnicity and female predominance were noted. Common manifestations included temporal headache (82.2%) and neuro-ophthalmic issues (68.9%).
  • Aortic aneurysms occurred in 6.6%. Relapses affected 28.9% of patients, with aspirin showing a protective effect.
  • Females exhibited higher rates of polymyalgia rheumatica and jaw claudication; males had more permanent visual loss.

Conclusions:

  • Brazilian GCA patients share many features with international cohorts, but present a notably higher prevalence of neuro-ophthalmic manifestations and blindness.
  • Corticosteroids (prednisone, methylprednisolone) and methotrexate were primary treatments.
  • Low-dose aspirin demonstrated a protective role in preventing GCA relapses.