Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spindle coma: observations and thoughts.

A Nogueira de Melo1, G L Krauss, E Niedermeyer

  • 1Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, Sao Paulo, Brazil.

Clinical EEG (Electroencephalography)
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The value of the EEG in diagnosis, treatmen,t and prognosis of childhood epilepsy.

Pediatric annals·2014
Same author

Perampanel Study 207: long-term open-label evaluation in patients with epilepsy.

Acta neurologica Scandinavica·2012
Same author

Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures.

Neurology·2012
Same author

Lacosamide for the treatment of epilepsy.

Annals of medicine·2012
Same author

Minimizing pharmacodynamic interactions of high doses of lacosamide.

Acta neurologica Scandinavica·2011
Same author

Tolerability and safety of perampanel: two randomized dose-escalation studies.

Acta neurologica Scandinavica·2011

Spindle coma, a state of NREM sleep patterns, can occur from non-traumatic causes like metabolic, infectious, or hypoxic issues. This finding expands understanding beyond central nervous system trauma.

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Neurology

Background:

  • Spindle coma, characterized by NREM sleep physiological patterns, has been historically linked to central nervous system (CNS) trauma.
  • Previous research emphasized the etiological role of CNS trauma in spindle coma.
  • Emerging evidence suggests nontraumatic causes can also lead to this condition.

Observation:

  • This study analyzed 11 cases of spindle coma in patients with acute severe CNS conditions, aged 6 months to 46 years.
  • The patient cohort (n=861) excluded cases of CNS trauma.
  • Metabolic, infectious, and hypoxic etiologies were the most frequent causes observed.

Findings:

  • Spindle coma is hypothesized to be a combination of true sleep and coma, resulting from impaired arousal mechanisms in the midbrain's reticular formation.

Related Experiment Videos

  • The presence of sleep elements like spindles, vertex waves, and K complexes suggests preserved cerebral hemisphere function.
  • This pattern can manifest in nontraumatic CNS pathologies, not exclusively in trauma cases.

    • Implications:

    • The findings broaden the etiological understanding of spindle coma beyond CNS trauma.
    • This research highlights the importance of considering metabolic, infectious, and hypoxic conditions in diagnosing spindle coma.
    • Understanding the neurophysiological underpinnings of spindle coma aids in diagnosing and managing severe acute CNS conditions.