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Neuropsychiatric side effects of cyclobenzaprine
David Shprecher1, Colgan T Sloan, Benson Sederholm
1Department of Neurology, University of Utah, Salt Lake City, Utah, USA. david.shprecher@hsc.utah.edu
Abstract:
Cyclobenzaprine is commonly used as a muscle relaxant and analgesic. Given its tricyclic properties, serotonin syndrome is a potential side effect of this drug. We report an unusual case of a patient who experienced symptoms of delirium and hyperkinetic movement disorders shortly after initiating treatment with cyclobenzaprine and oxycodone. Symptoms resolved within 48 h of discontinuing cyclobenzaprine. This case serves to remind clinicians to monitor for serotonin syndrome when initiating cyclobenzaprine, and when adding opiate or antidepressant medications to the regimen.
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