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Basic fibroblast growth factor in human pituitary tumours.

J J Silverlight1, R A Prysor-Jones, J S Jenkins

  • 1Division of Biochemical Medicine, St. George's Hospital Medical School, London, UK.

Clinical Endocrinology
|May 1, 1990
PubMed
Summary

Reduced levels of basic fibroblast growth factor (FGF) were found in most human pituitary tumors. This decrease in FGF may promote pituitary tumor growth, contrasting with its known inhibitory effects.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Basic fibroblast growth factor (FGF) plays a role in cell growth and differentiation.
  • Previous studies suggest basic FGF inhibits human pituitary tumor cell proliferation.

Purpose of the Study:

  • To quantify immunoreactive basic FGF levels in normal human pituitary glands and pituitary tumors.
  • To investigate the relationship between basic FGF content and pituitary tumor characteristics.

Main Methods:

  • Radioimmunoassay was used to measure basic FGF in pituitary tissue.
  • Gel column chromatography was employed to characterize pituitary FGF forms.

Main Results:

  • Normal pituitary glands showed a wide range of basic FGF (29.4–355 fmol/mg).

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  • 87.5% of pituitary tumors had lower basic FGF levels than normal glands.
  • Pituitary FGF exhibited heparin-binding affinity similar to basic FGF.
  • The majority of pituitary FGF existed as high molecular weight forms, not the basic peptide.

    • Conclusions:

    • Many pituitary tumors exhibit reduced basic FGF levels compared to normal tissue.
    • The diminished presence of basic FGF in pituitary tumors may contribute to tumor growth stimulation.
    • Further research is warranted to elucidate the precise role of FGF in pituitary tumorigenesis.