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Pituitary granulomatosis with polyangiitis.
1Division of Endocrinology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
BMJ Case Reports
|May 7, 2013
Summary
Granulomatosis with polyangiitis (GPA) rarely affects the pituitary gland, often causing permanent diabetes insipidus. This case highlights extensive pituitary damage involving both anterior and posterior regions, even after disease remission.
Area of Science:
- Endocrinology
- Rheumatology
- Neurology
Background:
- Granulomatosis with polyangiitis (GPA) is a rare small vessel vasculitis.
- GPA commonly affects the respiratory tract and kidneys.
- Pituitary gland involvement in GPA is exceptionally rare.
Observation:
- This report details a rare case of GPA affecting the pituitary gland.
- The patient presented with involvement of both anterior and posterior pituitary.
- Symptoms included diabetes insipidus, a common manifestation of posterior pituitary infiltration.
Findings:
- The case demonstrates extensive pituitary infiltration by GPA.
- Permanent pituitary insufficiency resulted from the disease.
- Damage occurred despite remission of the underlying granulomatous disease.
Implications:
- Highlights the potential for severe, permanent pituitary damage in GPA.
- Emphasizes the need for vigilance in diagnosing pituitary involvement in GPA patients.
- Suggests long-term endocrine monitoring may be necessary for affected individuals.
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