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Increased risk of CVD after VT is determined by common etiologic factors

Rachel E J Roach1, Willem M Lijfering, Linda E Flinterman

  • 1Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

Blood
|May 7, 2013
PubMed

Insights

Individuals with venous thrombosis (VT) face a higher risk of subsequent cardiovascular disease (CVD). Common underlying causes may explain this increased CVD risk in VT patients.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Epidemiology

Background:

  • Patients diagnosed with venous thrombosis (VT) exhibit an elevated risk for developing subsequent cardiovascular disease (CVD).
  • The precise pathophysiological mechanisms linking VT and CVD remain incompletely understood.
  • Understanding this association is crucial for risk stratification and preventative strategies in VT patients.

Purpose of the Study:

  • To investigate the incidence of cardiovascular disease (CVD) in patients with a history of venous thrombosis (VT).
  • To compare CVD risk in VT patients against both general population controls and partner controls, accounting for shared lifestyle factors.
  • To explore potential shared etiologic factors contributing to both VT and CVD.

Main Methods:

  • A prospective follow-up study involving 4480 VT patients, 2926 partner controls, and 2638 random digit dialing (RDD) controls.
  • Data collection spanned from 1999 to 2008, with a median follow-up of 5 years.
  • Incidence rates and hazard ratios for CVD (myocardial infarction or ischemic stroke) were calculated and adjusted for multiple confounders, including demographics, lifestyle factors, and thrombophilia markers.

Main Results:

  • A total of 124 CVD events were recorded during the follow-up period.
  • VT patients demonstrated a higher incidence of CVD compared to both RDD controls and partner controls.
  • Adjusted analyses revealed a persistent, though attenuated, increased risk of CVD in VT patients compared to control groups.

Conclusions:

  • Individuals with a history of venous thrombosis (VT) experience an increased risk of subsequent cardiovascular disease (CVD).
  • The findings suggest that shared underlying etiologic factors may contribute to the co-occurrence of VT and CVD.
  • Further research into these common factors is warranted to improve patient management and preventative care.

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