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Long noncoding RNAs in biology and hematopoiesis
Vikram R Paralkar1, Mitchell J Weiss
1Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Blood
|May 7, 2013
Summary
Long noncoding RNAs (lncRNAs) regulate gene expression without protein coding. These molecules likely play significant roles in hematopoiesis, the process of blood cell formation.
Area of Science:
- Molecular Biology
- Genomics
- Cell Biology
Background:
- Eukaryotic cells possess numerous noncoding RNAs, including long noncoding RNAs (lncRNAs).
- LncRNAs regulate gene expression independently of protein-coding potential.
- LncRNAs influence gene expression via epigenetic control, mRNA stability, and protein localization.
Purpose of the Study:
- To explore the potential roles of lncRNAs in hematopoiesis.
- To highlight the understudied nature of lncRNAs in blood cell development.
Main Methods:
- Genome sequencing
- Transcriptome sequencing
Main Results:
- Identification of a rich assortment of noncoding RNAs in eukaryotes.
- Demonstration of lncRNA involvement in diverse gene regulatory processes.
- Inference of likely widespread roles for lncRNAs in hematopoiesis.
Conclusions:
- LncRNAs are key regulators of gene expression in eukaryotes.
- Further research into lncRNAs in hematopoiesis is warranted.
- LncRNAs are predicted to have significant functions in blood cell development.
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