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Updated: May 11, 2026
10:27
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
Long non-coding RNAs (lncRNAs) and viral infections
1Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, the National Institutes of Health, Bethesda, Maryland 20892-0460, USA.
Summary
Long non-coding RNAs (lncRNAs) play crucial roles in virus replication within infected cells. This review highlights key cellular and viral lncRNAs and their functions.
Area of Science:
- Molecular Biology
- Virology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in cellular processes.
- The involvement of lncRNAs in viral infections is an emerging area of research.
Purpose of the Study:
- To review the current understanding of lncRNA involvement in virus replication.
- To highlight the functions and interactions of specific cellular and viral lncRNAs during infection.
Main Methods:
- Literature review and synthesis of existing research on lncRNAs and viral replication.
- Survey of identified cellular lncRNAs (e.g., XIST, HOTAIR, NEAT1, BIC) and viral lncRNAs.
Main Results:
- lncRNAs, both host-encoded and viral-encoded, significantly influence viral replication dynamics.
- Specific lncRNAs like XIST, HOTAIR, NEAT1, and BIC have demonstrated roles in modulating host-pathogen interactions and viral life cycles.
Conclusions:
- lncRNAs represent critical regulators in the interplay between viruses and host cells.
- Targeting lncRNAs may offer novel therapeutic strategies against viral infections.
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