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Updated: May 11, 2026
A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
Published on: March 1, 2018
Poly(pyrocatechol-3,5-disodiumsulfonate)/multi-walled carbon nanotubes composite for simultaneous determination of
Ying Xue1, Hong Zhao, Zhijiao Wu
1College of Chemistry and Chemical Engineering, Graduate University of Chinese Academy of Sciences, 100049 Beijing, China.
Abstract:
A novel poly(pyrocatechol-3,5-disodiumsulfonate)/multi-walled carbon nanotubes (PPD/MWCNT) composite film modified glassy carbon electrode (GCE) was fabricated and successfully used to simultaneously determine ascorbic acid (AA), dopamine (DA) and uric acid (UA). Owing to the synergistic effects of PPD and MWCNTs, the electrochemical responses of AA, DA and UA at PPD/MWCNTs/GCE were clearly superior to those at bare GCE. Additionally, the PPD/MWCNTs composite film could reduce the potential overlap of AA, DA and UA so as to favor simultaneous determination of the three substances. Under the optimum conditions, the linear calibration curves of AA, DA and UA were obtained by differential pulse voltammetry in the range of 10-1000, 1-100 and 4-1200 microM, and the detection limits were 5, 0.5 and 0.5 microM (S/N = 3) respectively. The results showed PPD/MWCNTs/GCE possessed good reproducibility and stability, and it could be applied to determine UA in human urine with satisfying recovery by standard addition method.
