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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: May 11, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Can we develop pathology-specific MRI contrast for "MR-negative" epilepsy?

Kirk W Feindel¹

¹School of Biomedical Engineering & Department of Radiology, Dalhousie University, Halifax, Nova Scotia, Canada. kirk.feindel@dal.ca

|May 8, 2013

Summary

Advanced magnetic resonance imaging (MRI) techniques like diffusional kurtosis imaging (DKI) and chemical exchange saturation transfer (CEST) offer new ways to detect epilepsy causes missed by standard MRI scans.

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Area of Science:

Medical Physics
Neuroimaging
Epileptology

Background:

Standard MRI struggles to identify epilepsy causes due to reliance on bulk tissue properties.
Improvements in MRI hardware and software are reducing but not eliminating "MR-negative" epilepsy cases.

Purpose of the Study:

To review novel MR physics techniques for improved epilepsy diagnosis.
To explore the potential of advanced MRI methods in identifying pathologies in "MR-negative" epilepsy.

Main Methods:

Discussion of advanced MRI techniques including diffusional kurtosis imaging (DKI), temporal diffusion spectroscopy, and chemical exchange saturation transfer (CEST).
Focus on how these methods characterize tissue substructure and biochemical processes beyond standard MRI contrasts (T1, T2, diffusion-weighted).

Main Results:

DKI and temporal diffusion spectroscopy offer insights into tissue microstructure.
CEST imaging targets specific biochemical processes relevant to epilepsy pathologies.

Conclusions:

Novel MR physics techniques show promise in improving the detection of epilepsy causes.
These advanced methods could significantly reduce the burden of "MR-negative" epilepsy by providing pathology-specific contrast.