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Related Experiment Videos

Left ventricular diastolic function in sepsis.

S M Jafri1, S Lavine, B E Field

  • 1Department of Medicine, Detroit Receiving Hospital, Wayne State University, MI.

Critical Care Medicine
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

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Diastolic dysfunction is common in sepsis, with or without septic shock. Patients showed abnormal diastolic filling patterns, indicating increased reliance on atrial contraction for filling the ventricles.

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Physiology

Background:

  • Systolic dysfunction is known in septic shock and sepsis without shock.
  • Diastolic abnormalities in these conditions are less understood.

Purpose of the Study:

  • To characterize diastolic filling abnormalities in patients with septic shock (SS) and sepsis without shock (SWS).

Main Methods:

  • Pulsed Doppler transmitral spectral tracings were used to assess diastolic filling.
  • 13 patients with SS, 10 with SWS, and 33 controls were studied.

Main Results:

  • Patients with SS and SWS exhibited abnormal diastolic filling compared to controls.
  • Key findings include increased peak atrial velocity, decreased peak rapid filling velocity/peak atrial filling velocity ratio, increased atrial filling fraction, and prolonged atrial filling period.

Related Experiment Videos

  • Heart rates were significantly higher in SS and SWS patients.
  • Conclusions:

    • Diastolic dysfunction is present in patients with systemic infections, including sepsis with and without shock.
    • Increased reliance on atrial systolic contribution to ventricular filling was observed in septic patients.