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Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

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Related Experiment Video

Updated: May 11, 2026

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

Industry Update: the latest developments in therapeutic delivery.

Oliver C Steinbach¹

¹Philips Healthcare, Clinical Science & Research Programs, Philips Healthcare - Clinical Research Board, 3000 Minuteman Road, Andover, MA 01810, USA. oliver.steinbach@philips.com

Therapeutic Delivery

|May 8, 2013

Summary

The pharmaceutical industry faces challenges but shows recovery in drug delivery deals. Focus is shifting to patient compliance through altered oral delivery and alternative administration routes.

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Last Updated: May 11, 2026

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

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Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice

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Published on: October 3, 2011

Area of Science:

Pharmaceutical industry analysis
Healthcare market trends
Drug delivery innovations

Background:

The US healthcare market faces challenges including fiscal policy and healthcare reform.
The pharmaceutical industry suffers from low public perception.
The drug delivery sector experienced a decline in deals in 2012 but shows signs of recovery.

Purpose of the Study:

To provide an industry update on drug delivery partnering deals and trends.
To highlight the shift towards patient compliance in drug delivery.
To identify emerging trends in alternative drug administration routes.

Main Methods:

Information sourced from company press releases, regulatory and patent agencies.
Analysis of scientific literature.
Review of recent licensing deals and financing rounds in the drug delivery sector.

Main Results:

A slight recovery in drug delivery partnering deals was observed in 2012 after a decline.
Increased emphasis on altered oral delivery profiles for patient compliance.
Growing interest in alternative administration routes like nasal and sublingual, despite bioavailability challenges.

Conclusions:

The pharmaceutical industry is expected to see a trend reversal in 2013 with companies refilling pipelines.
Patient compliance is a key driver for innovation in oral drug delivery.
While alternative administration routes are gaining traction, challenges in bioavailability and dosing remain.