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Updated: May 11, 2026

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
Published on: March 17, 2023
Functional tricuspid regurgitation: an underestimated issue
Michele Di Mauro1, Gian Paolo Bezante, Angela Di Baldassarre
1Department of Cardiology, University of L'Aquila, L'Aquila, Italy.
Functional tricuspid regurgitation (FTR), a common valve leakage, is often underestimated. Early correction of FTR, even when mild, is recommended due to its unfavorable prognosis and impact on survival.
Area of Science:
- Cardiology
- Cardiac Surgery
- Echocardiography
Background:
- Functional tricuspid regurgitation (FTR) is often overlooked despite its prevalence, affecting up to 89% of patients when any grade is considered.
- FTR occurs with structurally normal tricuspid valve leaflets and chordae, often secondary to conditions like mitral valve disease, pulmonary hypertension, and atrial fibrillation.
Purpose of the Study:
- To review the current understanding of functional tricuspid regurgitation.
- To highlight the clinical significance, diagnostic approaches, and management strategies for FTR.
Main Methods:
- Review of existing literature on functional tricuspid regurgitation.
- Assessment of diagnostic modalities including 2D and 3D transthoracic echocardiography (TTE) and transesophageal echocardiography.
- Analysis of surgical outcomes for tricuspid valve annuloplasty.
Main Results:
- Moderate or greater FTR is prevalent in approximately 16% of cases and is a risk factor for reduced survival.
- FTR, regardless of severity, tends to progress over time.
- Tricuspid valve annuloplasty is the standard surgical treatment, with a 1-year recurrence rate of 2.5–5.5% for moderate or severe FTR.
Conclusions:
- FTR is an underappreciated condition with a significant impact on patient outcomes.
- Early intervention for FTR, particularly during mitral valve surgery, is advisable.
- Tricuspid valve annuloplasty offers a viable surgical solution, though recurrence is possible.
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