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Atopic diathesis in patients with Kawasaki disease

Chian-Yaw Hwang1, Yu-Ya Hwang, Yi-Ju Chen

  • 1Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, Republic of China.

The Journal of Pediatrics
|May 8, 2013
PubMed

Insights

Kawasaki disease (KD) is linked to a higher risk of atopic diseases like atopic dermatitis in young children. Many children developed these conditions after their KD diagnosis.

Area of Science:

  • Pediatrics
  • Immunology
  • Dermatology

Background:

  • Kawasaki disease (KD) is an acute febrile illness affecting young children.
  • Atopic diathesis, including atopic dermatitis (AD), allergic rhinitis, and asthma, is common in childhood.
  • The relationship between KD and atopic conditions requires further investigation.

Purpose of the Study:

  • To investigate the association between Kawasaki disease and atopic diathesis in children under five.
  • To explore the temporal relationship between KD and the development of atopic diseases.

Main Methods:

  • Nationwide population-based study using Taiwan's National Health Insurance Research Database (1997-2010).
  • Included 200 children diagnosed with KD (under 5 years) and 800 age- and sex-matched controls.
  • Analyzed the risk of concomitant atopic diseases in KD patients.

Main Results:

  • Patients with KD showed an increased risk of any atopic disease (OR 1.61).
  • A significant increased risk of atopic dermatitis (AD) was observed in male patients aged 1-5 years (OR 3.02).
  • Over 60% of atopic diseases developed after the KD diagnosis.

Conclusions:

  • An association exists between Kawasaki disease and an increased risk of atopic dermatitis.
  • The onset of atopic diseases frequently follows an episode of Kawasaki disease.
Abstract

Keywords:
ADARAllergic rhinitisAtopic dermatitisCAACoronary artery aneurysmICD-9International Classification of Diseases, Ninth RevisionKDKawasaki diseaseLHID2000Longitudinal Health Insurance Database 2000

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