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Updated: May 11, 2026
09:20
An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
Published on: May 4, 2021
New pathways to control inflammatory responses in adipose tissue
Rand T Akasheh1, Jingbo Pang, Jason M York
1Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA.
Current Opinion in Pharmacology
|May 8, 2013
Summary
Obesity-linked adipose tissue inflammation drives comorbidities. This review highlights inflammasomes, T regulatory cells, and inflammation resolution mediators as potential therapeutic targets for obesity.
Area of Science:
- * Immunology and metabolic disease research.
- * Pharmacological targeting of inflammatory pathways.
Background:
- * Obesity is associated with chronic adipose tissue inflammation, particularly visceral fat.
- * This inflammation is a key factor in obesity-associated comorbidities and insulin resistance.
- * Current research focuses on understanding these inflammatory mechanisms for therapeutic intervention.
Purpose of the Study:
- * To review recent evidence on pharmacological targets for adipose tissue inflammation.
- * To identify mediators studied in chronic inflammatory diseases as potential obesity therapies.
- * To explore novel agonist therapies for inflammation resolution.
Main Methods:
- * Literature review of recent scientific evidence.
- * Focus on inflammasomes, T regulatory cells, and inflammation resolution mediators.
- * Analysis of potential therapeutic candidates for obesity-associated inflammation.
Main Results:
- * The inflammasome pathway and its products are identified as a key target for anti-inflammatory strategies.
- * T regulatory (Treg) cells show potential in modulating adipose tissue inflammation.
- * Mediators of inflammation resolution, including resolvins, protectins, annexin A1 (ANXA1), and galectins, are promising targets for novel therapies.
Conclusions:
- * Targeting adipose tissue inflammation offers a promising therapeutic avenue for obesity and its comorbidities.
- * Inhibiting inflammasomes and activating Treg cells are viable anti-inflammatory strategies.
- * Novel agonist therapies targeting inflammation resolution mediators present new opportunities for treatment.
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