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Static magnetic field induced hypovitaminosis D in rat
Lahbib Aïda1, Lecomte Frédéric, Ghodbane Soumaya
1Laboratory of Integrative Physiology, Faculty of Sciences of Bizerte, Carthage University, Jarzouna, Tunisia.
Abstract:
In the following study, we mainly investigate the effects of static magnetic field (SMF) (128 mT, 1 hr/day during 5 consecutive days) on 25-hydroxyvitamin D3 and calcium homeostasis. Wistar male rats, weighing 50-70 g, were randomly divided into four experimental groups: control, SMF-exposed rat, co-exposed rats (the last day and after exposure rats received a single dose of vitamin D per os) and supplemented with vitamin D group (without exposure to SMF). Exposure to SMF induced a decrease of plasmatic 25-hydroxyvitamin D3 level (P < 0.001). While, calcium and phosphorus levels were not affected (P > 0.05). The same treatment failed also to alter body, relative liver and kidney weights. Interestingly, oral supplementation with vitamin D corrected hypovitaminosis D induced by SMF. Likewise, the same treatment failed to alter calcium homeostasis. More studies are needed to evaluate how SMF induces hypovitaminosis D.
Insights
Static magnetic field (SMF) exposure decreased 25-hydroxyvitamin D3 levels in rats. Oral vitamin D supplementation effectively corrected this SMF-induced hypovitaminosis D, though calcium homeostasis remained unaffected.
Area of Science:
- Biophysics
- Endocrinology
- Nutritional Science
Background:
- Static magnetic fields (SMF) are increasingly utilized in various applications.
- The biological effects of SMF exposure, particularly on vitamin D metabolism, require further investigation.
- Understanding the interplay between SMF and calcium homeostasis is crucial for public health.
Purpose of the Study:
- To investigate the impact of controlled static magnetic field (SMF) exposure on 25-hydroxyvitamin D3 levels and calcium homeostasis in Wistar male rats.
- To assess the efficacy of vitamin D supplementation in counteracting potential SMF-induced alterations in vitamin D status and calcium balance.
Main Methods:
- Wistar male rats were divided into four groups: control, SMF-exposed, co-exposed (SMF + vitamin D), and vitamin D supplemented.
- SMF exposure was administered at 128 mT for 1 hour daily over 5 consecutive days.
- Plasma levels of 25-hydroxyvitamin D3, calcium, and phosphorus were measured, along with body, liver, and kidney weights.
Main Results:
- SMF exposure significantly decreased plasma 25-hydroxyvitamin D3 levels (P < 0.001).
- No significant alterations were observed in calcium, phosphorus, body weight, or relative organ weights.
- Oral vitamin D supplementation successfully reversed the hypovitaminosis D induced by SMF exposure.
Conclusions:
- Static magnetic field exposure can induce hypovitaminosis D in rats.
- Vitamin D supplementation is effective in correcting SMF-induced decreases in 25-hydroxyvitamin D3.
- Further research is warranted to elucidate the precise mechanisms by which SMF affects vitamin D metabolism.
