Related Experiment Videos
Nitrofurantoin excretion in human milk.
1Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent-de-Paul, Paris, France.
Developmental Pharmacology and Therapeutics
|January 1, 1990
Summary
Nitrofurantoin is excreted in low amounts in breast milk, with less than 0.29% of the dose found in milk. This suggests minimal drug exposure for breastfed infants when mothers take nitrofurantoin.
Area of Science:
- Pharmacology
- Pharmacokinetics
- Maternal-fetal medicine
Background:
- Nitrofurantoin is a common urinary antiseptic used to treat infections.
- Assessing drug transfer into human milk is crucial for infant safety during breastfeeding.
- Limited data exists on nitrofurantoin excretion in breast milk.
Purpose of the Study:
- To quantify nitrofurantoin concentrations in human breast milk and plasma.
- To determine the percentage of nitrofurantoin dose excreted into breast milk.
- To evaluate the safety of nitrofurantoin use in lactating women.
Main Methods:
- Six healthy lactating women received either 50 mg or 100 mg of nitrofurantoin three times daily.
- Milk and plasma samples were collected at various time points after the fourth dose.
- Nitrofurantoin concentrations were measured using High-Performance Liquid Chromatography (HPLC).
Main Results:
- Nitrofurantoin was not detectable in milk before administration.
- Excretion in milk within 6 hours was 0.05-0.28% of the administered dose.
- The milk-to-plasma concentration ratio was approximately 2.2-2.3 at 3 hours post-dose.
Conclusions:
- Nitrofurantoin excretion into human breast milk is low.
- Lactating women taking nitrofurantoin result in minimal drug exposure for their breastfed infants.
- Further studies may be warranted to confirm long-term infant outcomes.