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Updated: May 11, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
[A case of alpha-fetoprotein-producing fetal gut-like small intestinal cancer]
Yasuyuki Tamai1, Kazuhiko Kobayashi, Yuji Haruki
1Department of Gastroenterology, Matsusaka Chuo General Hospital, Japan. yasuyuki.tamai@miekosei.or.jp
Abstract:
A 72-year-old Japanese woman was admitted because of vomiting and abdominal pain. An enhanced computed tomography scan showed a small intestinal obstruction due to ileal wall thickening and multiple liver metastases. Her serum alpha-fetoprotein (AFP) level was high at 1671.9ng/ml. An ileocecal resection was performed. The histological diagnosis was AFP-producing small intestinal cancer resembling the primitive gut epithelium of a fetus. The present case suggested that even intestinal cancer could produce AFP.
