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Effect of rhBMP-2 upon maxillary sinus augmentation: a comprehensive review
Laura Torrecillas-Martinez1, Alberto Monje, Michael A Pikos
1Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain.
Implant Dentistry
|May 8, 2013
Summary
Recombinant human bone morphogenetic protein-2 (rhBMP-2) shows osteoinductive and osteogenic capacity, supporting its use as an alternative to autogenous bone for sinus augmentation.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Oral and Maxillofacial Surgery
Background:
- Sinus augmentation is a common procedure in implant dentistry.
- Autogenous bone grafts are the gold standard but have limitations.
- Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a potential alternative biomaterial.
Purpose of the Study:
- To review recent in vitro and in vivo research on rhBMP-2 for sinus augmentation.
- To evaluate the effectiveness of rhBMP-2 as a grafting material.
Main Methods:
- Literature search of PubMed (1996-2012).
- Inclusion of randomized clinical trials and prospective human/animal studies.
- Focus on studies comparing rhBMP-2 to autogenous bone for sinus augmentation.
Main Results:
- 3 human and 4 animal studies met criteria.
- rhBMP-2 induced new bone formation comparable to autogenous bone in humans.
- Animal studies showed regular bone formation and maturation with rhBMP-2.
- New bone quality was similar to native bone.
Conclusions:
- rhBMP-2 exhibits osteoinductive and osteogenic properties.
- rhBMP-2 is a viable alternative to autogenous bone for sinus floor augmentation.
- Further research may solidify its role in regenerative dentistry.