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Updated: May 11, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
Published on: October 8, 2021
Microbial biosensors: engineered microorganisms as the sensing machinery
Miso Park1, Shen-Long Tsai, Wilfred Chen
1Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. miso@udel.edu
Abstract:
Whole-cell biosensors are a good alternative to enzyme-based biosensors since they offer the benefits of low cost and improved stability. In recent years, live cells have been employed as biosensors for a wide range of targets. In this review, we will focus on the use of microorganisms that are genetically modified with the desirable outputs in order to improve the biosensor performance. Different methodologies based on genetic/protein engineering and synthetic biology to construct microorganisms with the required signal outputs, sensitivity, and selectivity will be discussed.
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