Effect of allergen sensitization on external root resorption.

Area of Science:

• Biomedical Science
• Orthodontics
• Immunology

Background:

• External root resorption (ERR) is a common complication of orthodontic tooth movement (OTM).
• Previous studies suggest a link between allergic diseases and increased ERR rates.
• The precise mechanisms connecting allergic sensitization and ERR remain unclear.

Purpose of the Study:

• To investigate the impact of allergic sensitization on external root resorption (ERR) during orthodontic tooth movement (OTM).
• To explore the molecular pathways involved in allergen-induced ERR.
• To evaluate aspirin's potential therapeutic effect on ERR in sensitized individuals.

Main Methods:

• Utilized ovalbumin (OVA)-sensitized Brown-Norway rats to model allergic sensitization.
• Applied orthodontic force to induce tooth movement and measured ERR and OTM.
• Assessed the expression levels of RANKL, pro-inflammatory cytokines, and leukotriene B4 (LTB4) in periodontal tissues.
• Investigated the effects of low-dose aspirin administration on ERR and related molecular markers.

Main Results:

• Allergen-sensitized rats exhibited significantly greater ERR and OTM compared to controls.
• Increased expression of RANKL, pro-inflammatory cytokines, and LTB4 was observed in sensitized rats undergoing OTM.
• Low-dose aspirin treatment effectively suppressed ERR, RANKL, pro-inflammatory cytokines, and LTB4 levels in sensitized rats.

Conclusions:

• Allergen sensitization adversely affects external root resorption (ERR) during orthodontic tooth movement (OTM).
• The 5-lipoxygenase pathway and leukotriene B4 (LTB4) are implicated in allergen-induced ERR.
• Aspirin demonstrates potential as a therapeutic agent to mitigate ERR in the context of allergic sensitization.