Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 11, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Diffusion tensor magnetic resonance histology reveals microstructural changes in the developing rat brain.

Evan Calabrese1, G Allan Johnson

  • 1Center for In Vivo Microscopy, Department of Radiology, Box 3302 Duke University Medical Center, Durham, NC 27710, USA.

Neuroimage
|May 8, 2013
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-resolution mri guided whole mouse brain neuronal cell type atlas using deep learning.

Communications biology·2026
Same author

Segmenting with confidence through uncertainty quantification for brain tumor imaging.

NPJ digital medicine·2026
Same author

Laser Interstitial Thermal Therapy for Brain Metastases: Imaging Guidelines for Clinical Trials and Practice.

Neuro-oncology·2026
Same author

Brain tumor segmentation in Sub-Saharan Africa patient population: The BraTS-Africa challenge.

Neuro-oncology advances·2026
Same author

MRI Features for Differentiation of Meningioma DNA Methylation Groups.

AJNR. American journal of neuroradiology·2026
Same author

Multi-Institutional Annotated Multiparametric MRI Dataset of Pediatric High-Grade Gliomas.

Radiology. Artificial intelligence·2026

Diffusion tensor magnetic resonance histology (DT-MRH) tracks microstructural brain development in rats. This method reveals changes in white and gray matter, aiding future studies on neurodevelopmental diseases.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Biomedical Imaging

Background:

  • The postnatal period is critical for brain development, involving significant macro- and microstructural changes like myelination and cortical layering.
  • This developmental stage is vulnerable to insults, potentially causing neurological diseases.
  • Magnetic Resonance Imaging (MRI) is vital for studying neurodevelopment, with quantitative techniques like Diffusion Tensor Imaging (DTI) visualizing microstructural alterations.

Purpose of the Study:

  • To utilize Diffusion Tensor Magnetic Resonance Histology (DT-MRH) for tracking microstructural changes during normal rat brain postnatal development.
  • To correlate diffusion tensor parameter changes with cytoarchitectural alterations in developing white and gray matter.
  • To establish a foundational database of image sets for future research on rodent models of neurodevelopmental disorders.

More Related Videos

Diffusion Imaging in the Rat Cervical Spinal Cord
10:46

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Related Experiment Videos

Last Updated: May 11, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Diffusion Imaging in the Rat Cervical Spinal Cord
10:46

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Main Methods:

  • Employing DT-MRH to non-invasively visualize and quantify microstructural changes in the developing rat brain.
  • Analyzing diffusion tensor parameters in both white matter and gray matter regions.
  • Correlating imaging data with cytoarchitectural observations.

Main Results:

  • DT-MRH successfully tracked dynamic microstructural changes throughout postnatal brain development in rats.
  • Specific diffusion tensor parameter changes were identified in developing white and gray matter structures.
  • Observed imaging changes were correlated with underlying cytoarchitectural modifications.

Conclusions:

  • DT-MRH is a powerful tool for characterizing normal postnatal brain development at a microstructural level.
  • This study provides essential data and a resource for investigating neurodevelopmental abnormalities in rodent models.
  • The findings support the use of DT-MRH in preclinical research for neurological disease.