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Updated: May 11, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
The role of miR-155 in regulatory T cells and rheumatoid arthritis
D Spoerl1, I Duroux-Richard, P Louis-Plence
1Inserm U844, CHU Saint Eloi, INM, 80 rue Augustin Fliche, 34295 Montpellier cedex 5, France. dspoerl@postmail.ch
Abstract:
Recently, various micro(mi)RNAs have been found deregulated in the setting of rheumatoid arthritis (RA), but their role in the pathogenesis of this disease remains a matter of debate. In the meanwhile, increasing evidence indicates a defective function of regulatory T cells (Tregs) in RA. This review discusses relevant studies addressing the function of Tregs and Cytotoxic T-Lymphocyte Antigen 4 in RA, provides recent data on the role of miRNAs for Tregs homeostasis, and focuses on the role of miR-155 in Tregs. In a final perspective section we discuss the potential impact of therapeutic miR-155 modulation in RA.
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