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Serum biomarkers and the prognosis of AMI patients

S Wei1, L Mao, B Liu

  • 1Department of Cardiology, The Fourth Clinical Hospital of Harbin Medical University, Nangang District, 37 Yiyuan Str., 150001, Harbin, China, shipengwei@yahoo.com.

Herz
|May 8, 2013
PubMed

Insights

Serum lactate dehydrogenase (LDH) and total bilirubin (TB) levels, along with their ratio (LDH/TB), are key indicators for predicting major adverse cardiac events (MACE) in acute myocardial infarction (AMI) patients after percutaneous coronary intervention (PCI).

Area of Science:

  • Cardiology
  • Biomarkers
  • Prognostic Indicators

Background:

  • Serum lactate dehydrogenase (LDH) and total bilirubin (TB) are known to increase during acute myocardial infarction (AMI).
  • The specific influence of these biomarkers on the long-term prognosis of AMI patients remains incompletely understood.

Purpose of the Study:

  • To investigate the prognostic value of serum LDH, TB, and their ratio (LDH/TB) in patients with AMI.
  • To assess the association of these biomarkers with major adverse cardiac events (MACE) in AMI patients undergoing delayed percutaneous coronary intervention (PCI).

Main Methods:

  • A cohort of 239 AMI patients, who missed the primary PCI window and underwent delayed PCI, were enrolled.
  • Serum levels of high-sensitivity C-reactive protein (hs-CRP), TB, LDH, cystatin C, and uric acid were measured 24-48 hours post-symptom onset.
  • Patients were followed for an average of 3.2 years to record MACE, with multivariate COX analysis used for prognostic assessment.

Main Results:

  • Patients experiencing MACE exhibited significantly higher levels of hs-CRP, LDH, cystatin C, uric acid, and a higher LDH/TB ratio, alongside lower TB levels.
  • Multivariate COX analysis identified LDH, cystatin C, and the LDH/TB ratio as significant predictors of MACE.
  • These findings suggest a link between elevated oxidative stress markers and adverse outcomes in AMI patients.

Conclusions:

  • LDH, cystatin C, and the LDH/TB ratio are robustly associated with the prognosis of AMI patients undergoing elective PCI.
  • Higher levels of these biomarkers indicate increased oxidative stress and a greater likelihood of MACE.
  • These markers can aid in risk stratification and management of AMI patients.
Abstract

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