Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reverse Fosmidomycin Analogs as Bisubstrate Inhibitors: Binding Mode Elucidation and Mechanistic Insights.

Journal of medicinal chemistry·2026
Same author

Synthesis of potent human DHRS11 inhibitors and their efficacy against androgen-dependent proliferation and sensitivity to AKT inhibitor Capivasertib of triple-negative breast cancer cells.

European journal of medicinal chemistry·2026
Same author

Characterization of Novel Decenoic Acid Derivatives Exhibiting Cytotoxic Activity Against T98G Glioma Cells Under a Serum- and Glucose-deprived Condition.

Cell biochemistry and biophysics·2026
Same author

Investigation of the functional hot-spot residues of an enzyme by real-time monitoring of the enzymatic reaction using NMR and computational approaches.

Scientific reports·2026
Same author

Phosphatidylcholine with C26:0 moiety, a precursor of a diagnostic marker for X-ALD, is synthesized by LPLAT10/LPEAT2.

Journal of lipid research·2026
Same author

Practicing pharmacist education based on the experiences of medical support on the cruise ship Diamond Princess.

BMC medical education·2025

Related Experiment Video

Updated: May 11, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

[Structural biology for developing antimalarial compounds].

Nobutada Tanaka1, Tomonobu Umeda, Yoshio Kusakabe

  • 1School of Pharmacy, Showa University. ntanaka@pharm.showa-u.ac.jp

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|May 8, 2013
PubMed
Summary

Drug resistance in malaria parasites necessitates new treatments. Structure-function studies of Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase (PfSAHH) and 1-deoxy-D-xylulose reductoisomerase (PfDXR) reveal targets for novel antimalarial drug design.

More Related Videos

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases
09:13

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases

Published on: November 22, 2024

Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding
09:23

Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding

Published on: July 3, 2020

Related Experiment Videos

Last Updated: May 11, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases
09:13

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases

Published on: November 22, 2024

Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding
09:23

Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding

Published on: July 3, 2020

Area of Science:

  • Biochemistry
  • Structural Biology
  • Medicinal Chemistry

Context:

  • Plasmodium falciparum causes over a million malaria deaths annually.
  • Drug-resistant malaria strains demand novel therapeutic strategies.
  • Understanding Plasmodium protein structures is crucial for drug development.

Purpose:

  • To elucidate structure-function relationships of two key Plasmodium falciparum proteins: PfSAHH and PfDXR.
  • To identify structural differences for designing species-specific inhibitors.
  • To reveal the molecular mechanism of action for antimalarial drugs like fosmidomycin.

Summary:

  • Structural comparison of PfSAHH and human SAHH identified a single amino acid difference (Cys59 vs. Thr60) critical for inhibitor selectivity.
  • Crystal structure analysis of PfDXR/fosmidomycin complexes elucidated the molecular basis of its antimalarial activity.
  • These structure-function insights guide the development of new antimalarial compounds.

Impact:

  • Provides a basis for designing targeted PfSAHH inhibitors with improved species specificity.
  • Confirms fosmidomycin's efficacy and mechanism against malaria parasites.
  • Advances the search for more effective antimalarial therapies to combat drug resistance.