Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chloroplast proteostasis: Coupling chlorophyll and carotenoid metabolism and chlorophyll-binding protein homeostasis in plants.

Journal of experimental botany·2026
Same author

Switchable client specificity in a dual functional chaperone coordinates light-harvesting complex biogenesis.

Science advances·2025
Same author

Author Correction: Vascular Normalization Induced by Sinomenine Hydrochloride Results in Suppressed Mammary Tumor Growth and Metastasis.

Scientific reports·2024
Same author

Preliminary study of metabonomic changes during the progression of atherosclerosis in miniature pigs.

Animal models and experimental medicine·2024
Same author

Author Correction: Effect of intensity of sedimentary cover deformation on hydrocarbon accumulation in Dongying Sag, Bohai Bay Basin, China.

Scientific reports·2024
Same author

Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer.

Acta biochimica et biophysica Sinica·2024

Related Experiment Video

Updated: May 11, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Molecular-targeted agents combination therapy for cancer: developments and potentials.

Feifei Li1, Changqi Zhao, Lili Wang

  • 1Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Beijing, China; Gene Engineering and Biotechnology Beijing Key Laboratory, Beijing Normal University, Beijing, China; Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, China.

International Journal of Cancer
|May 8, 2013
PubMed
Summary

Combining molecular-targeted agents (MATs) shows promise for improving cancer chemotherapy. This strategy addresses tumor heterogeneity and complexity by targeting multiple pathways, potentially enhancing antitumor efficacy.

Keywords:
anticancer efficacychemotherapycombination therapymolecular-targeted agentsrelapsesignaling pathway

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Related Experiment Videos

Last Updated: May 11, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Area of Science:

  • Oncology
  • Pharmacology
  • Genetics

Background:

  • Current cancer chemotherapy faces limitations due to tumor heterogeneity and complex cell signaling.
  • Targeting single pathways is often insufficient for complete cancer eradication.

Purpose of the Study:

  • To summarize clinical and preclinical studies on combination chemotherapy strategies.
  • To evaluate the antitumor potential of various combination approaches.

Main Methods:

  • Review of studies combining cytotoxic agents with molecular-targeted agents (MATs).
  • Analysis of strategies involving co-inhibition of single, parallel, or compensatory pathways.
  • Evaluation of specific combination regimens.

Main Results:

  • Combination therapies, including cytotoxic agents with MATs, demonstrate potential for improved anticancer efficacy.
  • Targeting multiple pathways or compensatory mechanisms offers a promising strategy.
  • Specific combination studies are introduced and their antitumor potentials assessed.

Conclusions:

  • Combination strategies represent a significant advancement in cancer treatment.
  • Addressing tumor complexity through multi-targeted approaches is crucial for enhancing chemotherapy.
  • Further research into specific combinations is warranted to optimize therapeutic outcomes.