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Biological activity of N-terminal fragments of calcitonin gene-related peptide
C A Maggi1, P Rovero, S Giuliani
1Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
European Journal of Pharmacology
|April 10, 1990
Abstract:
The i.v. injection of human alpha-calcitonin gene-related peptide (CGRP) in urethane-anesthetized rats produced hypotension and tachycardia. The N-terminal fragments, CGRP-(1-12), CGRP-(1-15) and CGRP-(1-22) displayed biological activity, although with less potency than the natural peptide. These findings provide the first evidence for biological agonist activity of N-terminal CGRP fragments.