Is microvascular decompression surgery a high risk for postoperative nausea and vomiting in patients undergoing craniotomy?
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Updated: May 11, 2026

Microvascular Decompression: Salient Surgical Principles and Technical Nuances
Published on: July 5, 2011
Keita Sato1, Seijyu Sai, Takehiko Adachi
1Department of Anesthesiology, Kitano Hospital, 2-4-20 Ogimachi, Kita-ku, Osaka-city, 530-0025, Japan, keita.satohh@gmail.com.
Purpose:
Patients undergoing microvascular decompression surgery often experience postoperative nausea and vomiting (PONV). However, there is little information about the incidence of PONV after microvascular decompression. We hypothesized that microvascular decompression is an especially high-risk procedure for PONV in patients undergoing neurosurgery, and investigated risk factors related to PONV after neurosurgery.
Methods:
All patients who underwent craniotomy in our institution during a period of 2 years were investigated retrospectively. Medical charts were reviewed to identify PONV during the 24-h postoperative period and related risk factors. Multivariate logistic regression analysis was conducted to elucidate the impact of microvascular decompression on PONV after craniotomy.
Results:
Among 556 craniotomy cases, 350 patients met the inclusion criteria. Multivariate logistic regression analysis showed that microvascular decompression was an independent risk factor for PONV after craniotomy (odds ratio 5.38, 3.02-9.60), in addition to female gender, non-smoker status, amount of intraoperative fentanyl administered, and cerebrovascular surgery.
Conclusion:
In this retrospective study, microvascular decompression surgery was an especially high-risk factor for PONV in patients undergoing craniotomy. It may be necessary to adopt a combination of prophylactic methods to reduce the incidence of PONV after microvascular decompression.
Insights
Microvascular decompression surgery significantly increases the risk of postoperative nausea and vomiting (PONV) in neurosurgery patients. Identifying and managing risk factors is crucial for reducing PONV incidence after this procedure.
Area of Science:
- Neurosurgery
- Anesthesiology
- Patient Safety
Background:
- Postoperative nausea and vomiting (PONV) is a common complication following neurosurgery.
- Limited data exists on the specific incidence and risk factors for PONV after microvascular decompression (MVD).
Purpose of the Study:
- To investigate the incidence of PONV after microvascular decompression surgery.
- To identify risk factors associated with PONV in patients undergoing craniotomy.
- To determine if MVD is an independent risk factor for PONV.
Main Methods:
- Retrospective review of 556 craniotomy cases over two years.
- Identification of PONV within 24 hours postoperatively.
- Multivariate logistic regression analysis to assess risk factors, including MVD.
Main Results:
- Microvascular decompression was identified as an independent risk factor for PONV (OR 5.38).
- Other significant risk factors included female gender, non-smoker status, intraoperative fentanyl, and cerebrovascular surgery.
- 350 patients met the inclusion criteria from the initial 556 cases.
Conclusions:
- Microvascular decompression surgery is a significant risk factor for PONV.
- Prophylactic strategies should be considered to mitigate PONV risk in MVD patients.
- Further research may explore targeted interventions for high-risk neurosurgical patients.
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