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Norepinephrine and serotonin increase the vasoconstrictor response of the perfused rat tail artery to changes in
N Thorin-Trescases1, L Oster, J Atkinson
1Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Nancy, France.
European Journal of Pharmacology
|April 25, 1990
Abstract:
Vasoconstriction and changes in cytosolic free Ca2+ concentrations (fura 2 with dual wavelength excitation) were measured simultaneously in the perfused tail artery of the rat. Vasoconstrictors (norepinephrine and 5-HT) appear to modulate contraction not only by changing the cytosolic free Ca2+ concentration but also by modifying the sensitivity of the contractile proteins to Ca2+.