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Oncology comparative effectiveness research: a multistakeholder perspective on principles for conduct and reporting
Scott D Ramsey1, Sean D Sullivan, Shelby D Reed
1Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. sramsey@fhcrc.org
The Oncologist
|May 8, 2013
Summary
Comparative Effectiveness Research (CER) helps improve cancer care by providing evidence beyond traditional clinical trials. Understanding CER
Area of Science:
- Oncology
- Health Services Research
- Evidence-Based Medicine
Background:
- Comparative Effectiveness Research (CER) offers potential to improve cancer care decisions for patients, clinicians, and policymakers.
- Many oncologists are unfamiliar with the distinctions between CER and traditional evidence generation methods like clinical trials.
- Concerns exist regarding CER's potential to overwhelm decision-makers with information or genuinely enhance decision-making.
Purpose of the Study:
- To clarify the distinguishing features of CER compared to standard phase I-III clinical trials in oncology.
- To identify key themes and validity threats relevant to CER implementation in cancer care delivery.
- To address whether cancer research and evidence utilization possess unique characteristics.
Main Methods:
- Convened a panel of oncology professionals with diverse roles in cancer care delivery.
- Gathered insights from the panel to identify critical issues distinguishing CER in oncology.
- Focused on themes most relevant to busy decision-makers and potential threats to study validity.
Main Results:
- Identified five central themes crucial for CER in oncology.
- Highlighted fundamental threats to the validity of CER studies, termed the "kiss of death."
- Explored the unique aspects of evidence generation and use in cancer compared to other health issues.
Conclusions:
- CER offers a valuable but distinct approach to evidence generation in oncology.
- Understanding CER's unique characteristics and potential validity threats is essential for its effective application.
- Further discussion is needed on the specific nuances of evidence use in cancer care.
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