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Updated: May 11, 2026

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS
11:02

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Published on: May 12, 2011

Reversible reactivity by optic nerve astrocytes.

Daniel Sun1, Juan Qu, Tatjana C Jakobs

  • 1Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.

Glia
|May 8, 2013
PubMed
Summary
This summary is machine-generated.

Mild optic nerve head injury causes reversible astrocyte reactivity without axon damage. This suggests astrocyte reactivity is plastic and not inherently harmful, potentially preceding glial scarring.

Keywords:
fibrous astrocytesglaucomaglial remodelingwhite matter

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Last Updated: May 11, 2026

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Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury
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Published on: June 29, 2015

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Cell Biology

Background:

  • Reactive astrocytes are commonly studied in severe injury models.
  • Understanding astrocyte response to mild injury is crucial for neuroprotection.

Purpose of the Study:

  • To investigate astrocyte response in the optic nerve head to subtle injury.
  • To determine if this reactivity is reversible and impacts optic axons.

Main Methods:

  • Induced mild intraocular pressure elevation in optic nerve head models.
  • Assessed astrocyte morphology via microscopy.
  • Evaluated optic axon integrity using electron microscopy and transport assays.

Main Results:

  • Astrocytes showed reactive remodeling (hypertrophy, process retraction) peaking at three days.
  • No significant gene expression changes were observed.
  • No discernible optic axon damage or transport deficits occurred.
  • Morphological changes were fully reversible after insult removal.

Conclusions:

  • Astrocyte reactivity is a plastic phenomenon that can fully resolve.
  • Reactivity itself may not be detrimental to optic axons.
  • This reversible reactivity could represent early stages of glial scar formation.