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Lithium potentiates agonist formation of [3H]CDP-diacylglycerol in human platelets
S P Watson1, L Shipman, P P Godfrey
1Department of Pharmacology, Oxford, U.K.
European Journal of Pharmacology
|April 25, 1990
Abstract:
Thrombin stimulated a rapid formation of [3H]CDP-diacylglycerol in platelets prelabelled with [3H]cytidine. This response was increased in the presence of LiCl after a delay of 5 min; potentiation could be prevented by myo-inositol. Since Li+ inhibits the liberation of inositol from inositol phosphates, the conversion of diacylglycerol to phosphatidylinositol via CDP-diacylglycerol may be dependent on the regeneration of inositol from this pathway.