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Diffusion tensor imaging of normal-appearing white matter in unilateral cerebral arterial occlusive disease
Xiangshui Meng1, Qing Wang, Jinwen Hou
1Department of Radiology, Qi Lu Hospital of Shandong University, Jinan, China.
Purpose:
To use MR with diffusion tensor imaging (DTI) and conventional and high b value to assess diffusion changes in normal-appearing white matter (NAWM) in patients with unilateral, severe stenosis, or occlusion of the middle cerebral artery (MCA).
Materials And Methods:
In total, 28 patients with NAWM and unilateral, severe stenosis, or occlusion of the MCA underwent DTI with b values 1000 and 2200 s/mm(2) at 3.0T MR. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), radial diffusivity (eigenvalues λ1 , λ2 ), and axial diffusivity (eigenvalue λ3 ) were measured for the ipsilateral and contralateral corona radiata.
Results:
Mean FA was significantly lower for the ipsilateral than contralateral corona radiata with high b value, 2200 s/mm(2) , and ipsilateral corona radiata with conventional low b value, 1000 s/mm(2) (all P < 0.01). Mean ADC, λ1 , λ2 , and λ3 were significantly higher for the ipsilateral than contralateral corona radiata with high b value (all P < 0.05) but not for ipsilateral than contralateral corona radiata with low b value (P > 0.05).
Conclusion:
DTI with a high b value detects diffusion changes in NAWM in patients with unilateral, severe stenosis, or occlusion of the MCA not seen with conventional b value or conventional MRI contrasts.
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